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"Standing" Strong and Shining Bright | Warmly celebrating the publication of Dr. Jian Wang’s doctoral thesis in Tetrahedron Letters—his work at Wanbangde Pharmaceutical Group’s Postdoctoral Research Station!
Date:
28 Mar,2024
Recently, Dr. Jian Wang, a postdoctoral researcher at the Wanbangde Pharmaceutical Group’s Postdoctoral Research Station, has achieved significant progress in the field of scientific research. His groundbreaking study, titled "Green oxidative cyclization to access 2,5-disubstituted-1,3,4-oxadiazoles from aldehydes and hydrazide derivatives using FeBr3 catalyst and hydrogen peroxide," was published in Tetrahedron Letters. Dr. Wang served as the first author and corresponding author of the paper, with Professor Shengchang Xiang from Fujian Normal University acting as his collaborative mentor.
Platform Introduction
Tetrahedron Letters is published by Elsevier, one of the world's largest academic journal publishers. Elsevier’s journals are renowned for their high-quality peer-review standards and rigorous editorial processes, earning them a prestigious reputation and significant influence in academia. Founded in 1960, Tetrahedron Letters is a distinguished chemistry journal that primarily features research contributions from the fields of organic chemistry, biochemistry, and medicinal chemistry. The journal is dedicated to swiftly disseminating groundbreaking and impactful scientific findings, offering researchers a platform to share their latest discoveries with the global scientific community.
Dr. Wang Jian is the first postdoctoral fellow recruited by Wanbangde Pharmaceutical Group. He joined the program in May 2022, and currently, his research at the company on the synthesis process of ethyl 6,8-dichlorooctanoate has already achieved significant progress.
Overview of the paper's content
In the synthesis process of ethyl 6,8-dichlorooctanoate, it is often necessary to treat the resulting wastewater to meet environmental regulations. Given the promising potential of the Fenton reaction in wastewater treatment, integrating this technology into the synthesis of ethyl 6,8-dichlorooctanoate can effectively manage the wastewater generated during the process, converting organic compounds into harmless byproducts while achieving both wastewater purification and resource recovery. In this context, Dr. Jian Wang designed, completed, and published an article detailing the application of the Fenton reaction in the synthesis of 2,5-disubstituted-1,3,4-oxadiazoles.
First, the Fenton reaction is a widely used method in wastewater treatment, generating highly reactive hydroxyl radicals that efficiently degrade organic compounds in industrial effluents. In Dr. Wang Jian’s research, he leveraged the powerful oxidizing ability of the Fenton reaction to successfully synthesize 2,5-disubstituted-1,3,4-oxadiazoles, demonstrating both the feasibility and effectiveness of the Fenton reaction in organic synthesis.
This newly published paper demonstrates the synthesis of 2,5-disubstituted-1,3,4-oxadiazoles and their related derivatives using inexpensive iron salts as catalysts and environmentally friendly hydrogen peroxide as the green oxidant. The method described in this study efficiently and rapidly converts aldehydes and acylhydrazine compounds into a diverse array of 2,5-disubstituted-1,3,4-oxadiazoles. Moreover, given the widespread presence of 2,5-disubstituted-1,3,4-oxadiazole derivatives in pharmaceuticals and bioactive compounds, this green oxidation approach stands out for its mild reaction conditions, broad substrate compatibility, tolerance toward air and water, and straightforward experimental procedure—making it a promising strategy with significant potential for practical applications.
The successful publication of this paper is a testament to Dr. Wang Jian’s outstanding research capabilities, and it also reflects the company’s success in attracting high-caliber talent and building a top-tier research team. This milestone marks another significant step forward in the company’s development of its postdoctoral workstation program.
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