Omeprazole Enteric-Coated Capsules

Capsule formulation, prescription medication

Category:

Hepatobiliary, Gastroenterology Series

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Product Description

· National Essential Medicines List Products
· National Medical Insurance Products
· First-choice medication for treating gastrointestinal ulcers

Specifications: 20mg
Drug category: Western medicine
National Medical Insurance: Class A

Indications: Suitable for gastric ulcers, duodenal ulcers, stress-induced ulcers, reflux esophagitis, and Zollinger-Ellison syndrome (gastrinoma).

Pharmacology and Toxicology: Proton pump inhibitors. This product is a lipid-soluble, weakly basic drug that readily accumulates in acidic environments. After oral administration, it specifically distributes into the secretory canaliculi of gastric parietal cells, where it transforms into its active sulfonamide form under highly acidic conditions. This active form then forms an irreversible covalent bond with the sulfhydryl groups of the H⁺,K⁺-ATPase enzyme (also known as the proton pump) located in the parietal cell's secretory membrane—specifically through a disulfide bridge. The resulting sulfonamide-proton pump complex effectively inhibits the enzyme's activity, blocking the final step of gastric acid secretion. As a result, this medication exerts a potent and long-lasting suppression of acid production, regardless of the underlying cause.